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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Carbamoyl phosphate synthase II ： ウィキペディア英語版 Carbamoyl phosphate synthase II Carbamoyl phosphate synthetase II () is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in the cytosol (as opposed to type I, which functions in the mitochondria). Its systemic name is ''hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)''. In pyrimidine biosynthesis, it serves as the rate-limiting enzyme and catalyzes the following reaction: : 2 ATP + L-glutamine + HCO3− + H2O $\backslash rightleftharpoons$ 2 ADP + phosphate + L-glutamate + carbamoyl phosphate (overall reaction) : (1a) L-glutamine + H2O $\backslash rightleftharpoons$ L-glutamate + NH3 : (1b) 2 ATP + HCO3− + NH3 $\backslash rightleftharpoons$ 2 ADP + phosphate + carbamoyl phosphate It is activated by ATP and PRPP〔https://www.inkling.com/read/illustrated-reviews-biochemistry-harvey-5th/chapter-22/pyrimidine-synthesis-and〕 and it is inhibited by UMP (Uridine monophosphate, the end product of the pyrimidine synthesis pathway). Neither CPSI nor CPSII require biotin as a coenzyme, as seen with most carboxylation reactions. It is one of the three enzyme functions coded by the CAD gene. It is classified under . == Nomenclature == Carbamoyl-phosphate synthase (glutamine-hydrolysing) is also known as: * hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) * carbamyl phosphate synthetase (glutamine) * glutamine-dependent carbamyl phosphate synthetase * carbamoyl phosphate synthetase * CPS * carbon-dioxide:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Carbamoyl phosphate synthase II」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.